Prof. Otto Meyerhof, For.Mem.R.S.

Otto Fritz Meyerhof and the elucidation of the glycolytic pathway.

The elucidation of the glycolytic pathway, the process whereby glucose is converted into pyruvate and ATP, began in 1860 when Louis Pasteur observed that microorganisms were responsible for fermentation. Several years later, in 1897, Eduard Buchner made the significant discovery that cell-free extracts could carry out fermentation. The next important contribution was from Arthur Harden and Will...

The Origin of the Reaction of Harden and Young in Cell-free Alcoholic Fermentation* by Otto Meyerhof

Since adenosine triphosphate (ATP)l transfers its labile phosphate to glucose, for every mole of triose phosphate oxidized 1 mole of inorganic phosphate is taken up by the fermenting system. Besides this uptake, an internal cycle exists for the second phosphate group, which is already present in the triose phosphate and after oxidation appears finally in the phosphopyruvic acid. This phosphate ...

Prof. Dr. Prof. Prof.

Otto Loewi

The end of the 19th century was the starting point of many discoveries in the field of the neurophysiology. At that time, only basic technical approaches were available, and new discoveries depended on few results and lots of deductions. Furthermore, the scientific community was often debating on theoretical speculations and was often divided. I have chosen to present a German neurophysiologist...

Biochemistry of Coxiella burnetii: Embden-Meyerhof pathway.

Purified preparations of Coxiella burnetii were examined for enzymes of the glycolytic pathway. Glucose-phosphate isomerase, fructose-1,6-diphosphatase, aldolase, glyceraldehyde-3-phosphate dehydrogenase, and pyruvate kinase were shown to be present in C. burnetii extracts. Heat-killed C. burnetii purified with normal yolk sacs demonstrated no activity after disruption. Aldolase was shown to be...